Effects of orchiectomy, alone or in combination with testosterone, and cyproterone acetate on exocrine pancreatic carcinogenesis in rats and hamsters.

Exocrine Pancreatic Carcinogenesis and Autotaxin Expression

Exocrine pancreatic cancer is an aggressive disease with an exceptionally high mortality rate. Genetic analysis suggests a causative role for environmental factors, but consistent epidemiological support is scarce and no biomarkers for monitoring the effects of chemical pancreatic carcinogens are available. With the objective to identify common traits for chemicals inducing pancreatic tumors we...

The Effects of Lead Acetate on Sexual Behavior and the Level of Testosterone in Adult Male Rats

هورمون تراپی در درمان آدنوکارسینومای پیشرفته پروستات مقایسه نتایج درمانی اختگی (جراحی یا مدیکال) و بلوک کامل آندروژن ها

Only orchiectomy is still commonly used today either as a single therapy or in combination regimens. Hypophysectomy & adrenalectomy showed such devastating effects on the endocrine equilibrium as to be inconsistent with an acceptable quality of life or even with survival. Chemical adrenalectomy was also tried with drugs (eg. aminoglutethmide, spironolactone) leading to consequences superimposab...

Effect of Crocin and Losartan on Insulin Resistance and Protecting Pancreatic Tissue in Streptozotocin-Induced Diabetic Rats

Background and purpose: Crocin as a carotenoid exert anti-inflammatory, anti-oxidant, and anti-diabetic effects. There is an increasing prevalence of diabetes mellitus and its complications and patients are more interested in natural product treatments. This study aimed at investigating the efficacy of crocin and losartan alone and combination of the two drugs on insulin resistance and protecti...

P-17: Effects of Garlic (Allium Sativum L), Vitamin E and Cystein on LH and Testosterone Hormone Level Related with Lead Toxicity in The Male Rat

Background: Lead (Pb) is one of the ubiquitous nonessential haevy metals in the environment. There are evidences, which show that lead toxicity has many undesired effects, including neurological, behavioral, immunological, renal, hepatic, male reproductive, dysfunctions. The objective of the present study was to investigate the effects of aqueous garlic extracts, vitamin E and N-Acetylcysteine ...